Profluent Raises $106M to Accelerate Frontier AI Models for Programmable Biology, Backed by Jeff Bezos
Profluent, an AI-driven biotech startup specializing in protein design, announced a $106 million financing round co-led by Altimeter Capital and Bezos Expeditions, with Jeff Bezos providing direct support123.
The new round brings Profluent’s total funding to $150 million since its founding in 202235.
Existing investors in this round include Spark Capital, Insight Partners, and Air Street Capital1235.
Profluent uses advanced large-scale AI models to generate functional proteins, aiming to make biology programmable for applications in drug development, diagnostics, agriculture, and biomanufacturing234.
Major scientific benchmarks include the first AI-designed CRISPR system from scratch and the creation of the proprietary Protein Atlas containing over 115 billion unique protein sequences — the world’s largest such resource234.
Their open-source gene editor, OpenCRISPR-1, is actively used by leading pharmaceutical companies and academic research groups around the world234.
Commercial traction is proven by partnerships with companies such as Revvity and Corteva Agrisciences234.
Profluent is expanding its platform capabilities beyond genome editors to include antibodies, antigens, enzymes, and other biologics, with the goal of developing AI-authored therapies for human health and environmental challenges35.
CEO Ali Madani stated that the funding will accelerate the transition from laboratory breakthroughs to practical, real-world applications235.
Profluent is positioning itself as a foundational partner for industries pursuing customized biological solutions powered by AI234.
Sources:
1. https://sfbn.org/san-francisco-biotech-news/2025/11/19/profluent-raises-106m-to-scale-frontier-ai-models-for-programmable-biology/
2. https://www.startuphub.ai/ai-news/funding-round/2025/profluent-secures-106-million-to-supercharge-frontier-ai-for-programmable-biology/
3. https://www.businesswire.com/news/home/20251119356889/en/Profluent-Raises-$106M-to-Scale-Frontier-AI-Models-for-Programmable-Biology
4. https://www.startuphub.ai/ai-news/funding-round/2025/profluent-secures-106-million-to-supercharge-frontier-ai-for-programmable-biology/?amp=1
5. https://bio.bakarlabs.org/profluent-raises-106m-to-scale-frontier-ai-models-for-programmable-biology/