Merck opens $1B Gardasil manufacturing facility in North Carolina

Merck has opened a new $1 billion vaccine manufacturing facility in Durham, North Carolina, dedicated to increasing production capacity for its HPV vaccine Gardasil123.

Key details about the new facility:

  • It is a 225,000-square-foot plant located at Merck's existing site in Durham35
  • The facility will manufacture Gardasil and Gardasil 9 vaccines, which protect against HPV78
  • Construction began in 2019 and the plant is now open, with manufacturing to start this year and ramp up in 20263
  • It's part of over $12 billion Merck has invested in U.S. manufacturing and R&D since 2018, with another $8 billion planned by 202835

The expansion highlights Merck's efforts to strengthen its U.S. manufacturing capabilities:

  • It will create new jobs, with Merck currently employing about 1,000 people at the Durham site3
  • The company chose Durham due to the strong local workforce3
  • The facility incorporates advanced technologies like data analytics, generative AI, and 3D printing5

This investment comes as Gardasil remains a key product for Merck, generating $8.6 billion in revenue last year3. However, the vaccine faces challenges including reduced shipments to China and upcoming patent expirations in 20286.

Sources:

1. https://endpts.com/merck-opens-billion-dollar-facility-to-make-bladder-cancer-immunotherapy/

2. https://pharmaphorum.com/news/msd-opens-1bn-plant-hpv-vaccine-us

3. https://www.bizjournals.com/triangle/news/2025/03/11/merck-durham-expansion-gardasil-hpv-vaccine-mrk.html

5. https://www.merck.com/news/merck-unveils-new-facility-to-increase-vaccine-production-capacity/

6. https://www.biospace.com/business/good-day-for-gardasil-as-merck-wins-safety-suit-drops-1b-for-manufacturing-push

7. https://www.pharmamanufacturing.com/industry-news/news/55273968/merck-opens-1b-vaccine-manufacturing-facility-as-part-of-north-carolina-expansion

8. https://www.thomasnet.com/insights/merck-north-carolina-vaccine-plant/

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