AstraZeneca and SOPHiA GENETICS Expand AI-Powered Cancer Testing Collaboration
AstraZeneca and SOPHiA GENETICS have announced an expanded multi-year collaboration to improve detection and treatment of breast and prostate cancer using AI-powered next generation sequencing (NGS) technologies135.
The partnership focuses on optimizing the detection of genetic mutations within the PIK3CA/AKT1/PTEN signaling pathway, which is implicated in the development and progression of these cancers135.
A prototype solution leveraging SOPHiA GENETICS's AI algorithms has demonstrated improved sensitivity for detecting complex mutations, particularly across the PTEN gene, which is key for cancer diagnosis and understanding resistance to treatments135.
AstraZeneca will utilize SOPHiA GENETICS's multimodal AI Factories to analyze genomics, imaging, and clinical data, aiming to generate new predictive models that optimize breast cancer patient outcomes24.
The collaboration includes a Privileged Access Program for select clinical labs and plans broader commercial rollout in 2026, alongside a multi-center real-world evidence study to validate effectiveness in actual healthcare settings13.
Real-world evidence generation across Europe and North America is a core aspect, enabling deeper understanding of treatment efficacy and improving clinical decision-making24.
This expansion strengthens SOPHiA GENETICS’s commercial reach and market position in precision oncology, reflecting industry demand for secure, compliant AI solutions in healthcare4.
Sources:
1. https://www.sophiagenetics.com/news/collaboration-with-astrazeneca-to-enhance-detection-of-breast-and-prostate-cancer/
2. https://www.prnewswire.com/news-releases/sophia-genetics-expands-collaboration-with-astrazeneca-using-ai-to-improve-breast-cancer-patient-outcomes-302521027.html
3. https://www.biospace.com/press-releases/sophia-genetics-expands-collaboration-with-astrazeneca-to-enhance-detection-of-breast-and-prostate-cancer
4. https://www.stocktitan.net/news/SOPH/sop-hi-a-genetics-expands-collaboration-with-astra-zeneca-using-ai-huwab81e6lye.html
5. https://investingnews.com/sophia-genetics-expands-collaboration-with-astrazeneca-to-enhance-detection-of-breast-and-prostate-cancer/