Posts

Inhibrx's OX40 Agonist INBRX-106 Doubles Tumor Response Rate with Keytruda in Head and Neck Cancer Trial

Inhibrx's phase 2 HexAgon study in treatment-naïve, high PD-L1 (CPS ≥20) metastatic HNSCC patients showed 44% ORR with INBRX-106 + Keytruda vs 21.4% with Keytruda alone. Combination arm had three complete responses and majority of responders with >50% tumor shrinkage. ORR aligns with Merck's phase 3 Keytruda monotherapy data (23.3%) in similar population. INBRX-106 attracted M&A interest from Merck & Co. and others, potentially valued over $8B. Progression-free survival data expected Q4; trial modeled on Merck's design for clear signal. Sources:

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