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BioMarin buys early-stage oral bone-disease drug from Alesta

BioMarin agreed to acquire Alesta Therapeutics for $275 million upfront, with up to $215 million in development and regulatory milestone payments. The deal gives BioMarin ALE1, an oral small-molecule candidate for hypophosphatasia (HPP), a rare genetic bone disease caused by ALPL mutations. ALE1 is in an ongoing Phase 1/2a trial and could become the first oral treatment for HPP, potentially offering an alternative to current injectable therapies. Although announced as an acquisition, it is effectively an asset-focused transaction: Alesta plans to spin out its other programs and employees into a separate company before closing. The transaction is expected to close in the third quarter of 2026 and will be funded with BioMarin’s cash on hand. Sources: BioMarin to Acquire Alesta Therapeutics to Gain ALE1, a Potential ... BioMarin snaps up Alesta's lead asset for $275M - pharmaphorum BioMarin does another small deal to get early-stage bone disease ... BioMarin inks $...

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